p-Cresyl sulfate

• CAT Number: I011783
• CAS Number: 3233-58-7
• Molecular Formula: C7H8O4S
• Molecular Weight: 188.197
• Purity: ≥95%
• Synonyms: p-tolyl hydrogen sulfate
• Target: Endogenous Metabolite
• Solubility: >9.4mg/mL in DMSO
• Storage: Store at -20°C
• IUPAC Name: (4-methylphenyl) hydrogen sulfate
• InChI: InChI=1S/C7H8O4S/c1-6-2-4-7(5-3-6)11-12(8,9)10/h2-5H,1H3,(H,8,9,10)
• InChIKey: WGNAKZGUSRVWRH-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)OS(=O)(=O)O

p-Cresyl sulfate(CAT: I011783) is a sulfate conjugate of p-cresol. It is formed in the body through the metabolism of p-cresol, a compound found in the intestines as a result of the breakdown of dietary protein by gut bacteria. p-Cresyl sulfate is considered a uremic toxin, meaning it is elevated in individuals with impaired kidney function. It has been associated with adverse effects on various organs and systems, including the cardiovascular system and the central nervous system. Elevated levels of p-cresyl sulfate have been linked to complications in chronic kidney disease patients.

Reference

1.Meijers, B. K. I., et al. "Free p-cresol is associated with cardiovascular disease in hemodialysis patients." Kidney international 73.10 (2008): 1174-1180.
2.Dou, Laetitia, et al. "The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair." Kidney international 65.2 (2004): 442-451.