For research use only. Not for therapeutic Use.
p-Cymene（Cat No.:I008569）, also referred to as p-Cymol, is an aromatic hydrocarbon derived from plants. It is utilized for its pain-relieving properties in rheumatic conditions. p-Cymene possesses anti-hyperalgesic effects, reducing sensitivity to pain, and exhibits anti-inflammatory properties, which help to alleviate inflammation. These characteristics make p-Cymene a valuable compound for managing pain associated with rheumatism.
| Catalog Number | I008569 |
| CAS Number | 99-87-6 |
| Synonyms | p-Cymene; Dolcymene; p-Cymol; p Cymene; pCymene; p Cymol; p-Cymol;;p-cymene |
| Molecular Formula | C10H14 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 2-8°C |
| IUPAC Name | 1-methyl-4-propan-2-ylbenzene |
| InChI | InChI=1S/C10H14/c1-8(2)10-6-4-9(3)5-7-10/h4-8H,1-3H3 |
| InChIKey | HFPZCAJZSCWRBC-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)C(C)C |
| Reference | </br>1:Comparative solution equilibrium studies of antitumor ruthenium(η<sup>6</sup>-p-cymene) and rhodium(η<sup>5</sup>-C<sub>5</sub>Me<sub>5</sub>) complexes of 8-hydroxyquinolines. Dömötör O, Pape VF, May NV, Szakács G, Enyedy ÉA.Dalton Trans. 2017 Mar 27;46(13):4382-4396. doi: 10.1039/c7dt00439g. PMID: 28287667 </br>2:p-Cymene as Solvent for Olefin Metathesis: Matching Efficiency and Sustainability. Granato AV, Santos AG, Dos Santos EN.ChemSusChem. 2017 Apr 22;10(8):1832-1837. doi: 10.1002/cssc.201700116. Epub 2017 Mar 21. PMID: 28230317 </br>3:Combination of ruthenium(II)-arene complex [Ru(η<sup>6</sup>-p-cymene)Cl<sub>2</sub>(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity. Berndsen RH, Weiss A, Abdul UK, Wong TJ, Meraldi P, Griffioen AW, Dyson PJ, Nowak-Sliwinska P.Sci Rep. 2017 Feb 22;7:43005. doi: 10.1038/srep43005. PMID: 28223694 Free PMC Article</br>4:p-Cymene Promotes Its Catabolism through the p-Cymene and the p-Cumate Pathways, Activates a Stress Response and Reduces the Biofilm Formation in Burkholderia xenovorans LB400. Agulló L, Romero-Silva MJ, Domenech M, Seeger M.PLoS One. 2017 Jan 10;12(1):e0169544. doi: 10.1371/journal.pone.0169544. eCollection 2017. PMID: 28072820 Free PMC Article</br>5:Structurally Related Monoterpenes p-Cymene, Carvacrol and Thymol Isolated from Essential Oil from Leaves of Lippia sidoides Cham. (Verbenaceae) Protect Mice against Elastase-Induced Emphysema. Games E, Guerreiro M, Santana FR, Pinheiro NM, de Oliveira EA, Lopes FD, Olivo CR, Tibério IF, Martins MA, Lago JH, Prado CM.Molecules. 2016 Oct 20;21(10). pii: E1390. PMID: 27775634 Free Article</br>6:Synthesis of Terephthalic Acid by p-Cymene Oxidation using Oxygen: Toward a More Sustainable Production of Bio-Polyethylene Terephthalate. Neaţu F, Culică G, Florea M, Parvulescu VI, Cavani F.ChemSusChem. 2016 Nov 9;9(21):3102-3112. doi: 10.1002/cssc.201600718. Epub 2016 Oct 12. PMID: 27731947 </br>7:Acaricidal activity of oregano oil and its major component, carvacrol, thymol and p-cymene against Psoroptes cuniculi in vitro and in vivo. Shang X, Wang Y, Zhou X, Guo X, Dong S, Wang D, Zhang J, Pan H, Zhang Y, Miao X.Vet Parasitol. 2016 Aug 15;226:93-6. doi: 10.1016/j.vetpar.2016.07.001. Epub 2016 Jul 2. PMID: 27514892 </br>8:Novel Antitumor Invasive Actions of p-Cymene by Decreasing MMP-9/TIMP-1 Expression Ratio in Human Fibrosarcoma HT-1080 Cells. Li J, Liu C, Sato T.Biol Pharm Bull. 2016;39(8):1247-53. doi: 10.1248/bpb.b15-00827. PMID: 27476935 Free Article</br>9:A dinuclear [{(p-cym)Ru(II)Cl}2(μ-bpytz˙(-))](+) complex bridged by a radical anion: synthesis, spectroelectrochemical, EPR and theoretical investigation (bpytz = 3,6-bis(3,5-dimethylpyrazolyl)1,2,4,5-tetrazine; p-cym = p-cymene). Tripathy SK, van der Meer M, Sahoo A, Laha P, Dehury N, Plebst S, Sarkar B, Samanta K, Patra S.Dalton Trans. 2016 Aug 2;45(31):12532-8. doi: 10.1039/c6dt01995a. PMID: 27435992 </br>10:Half-sandwich RuCl2(η(6)-p-cymene) core complexes containing sulfur donor aroylthiourea ligands: DNA and protein binding, DNA cleavage and cytotoxic studies. Jeyalakshmi K, Haribabu J, Bhuvanesh NS, Karvembu R.Dalton Trans. 2016 Aug 2;45(31):12518-31. doi: 10.1039/c6dt01167e. PMID: 27435011 |
