p-Nitro-Cyclic Pifithrin-α

For research use only. Not for therapeutic Use.

  • CAT Number: R029162
  • CAS Number: 60477-38-5
  • Molecular Formula: C15H13N3O2S
  • Molecular Weight: 299.348
  • Purity: ≥95%
Inquiry Now

p-Nitro-Cyclic Pifithrin-α (CAT: R029162) is known as an inactivator of p53, a tumor suppressor gene that regulates cell death in response to apoptotic stimuli and DNA damage. In neurodegenerative disorders, the activation of p53 may contribute to the degenerative processes leading to neuronal death. As such, p53 inhibitors like p-Nitro-Cyclic Pifithrin-α hold promise as potential therapeutic agents for suppressing degeneration in neurodegenerative disorders. By inhibiting p53 activity, this compound may help protect neurons from apoptotic stimuli and DNA-damaging agents, offering a potential avenue for treating or managing certain neurodegenerative diseases.


Catalog Number R029162
CAS Number 60477-38-5
Synonyms

5,6,7,8-Tetrahydro-2-(4-nitrophenyl)-imidazo[2,1-b]benzothiazole; Cyclic pifithrin-α-p-nitro

Molecular Formula C15H13N3O2S
Purity ≥95%
Target MDM-2/p53
Solubility Soluble in DMSO
Storage Store at -20°C
IUPAC Name 2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole
InChI InChI=1S/C15H13N3O2S/c19-18(20)11-7-5-10(6-8-11)12-9-17-13-3-1-2-4-14(13)21-15(17)16-12/h5-9H,1-4H2
InChIKey XMFNSEDROOHGBY-UHFFFAOYSA-N
SMILES C1CCC2=C(C1)N3C=C(N=C3S2)C4=CC=C(C=C4)[N+](=O)[O-]

Request a Quote