For research use only. Not for therapeutic Use.
p-Nitro-Cyclic Pifithrin-α (CAT: R029162) is known as an inactivator of p53, a tumor suppressor gene that regulates cell death in response to apoptotic stimuli and DNA damage. In neurodegenerative disorders, the activation of p53 may contribute to the degenerative processes leading to neuronal death. As such, p53 inhibitors like p-Nitro-Cyclic Pifithrin-α hold promise as potential therapeutic agents for suppressing degeneration in neurodegenerative disorders. By inhibiting p53 activity, this compound may help protect neurons from apoptotic stimuli and DNA-damaging agents, offering a potential avenue for treating or managing certain neurodegenerative diseases.
Catalog Number | R029162 |
CAS Number | 60477-38-5 |
Synonyms | 5,6,7,8-Tetrahydro-2-(4-nitrophenyl)-imidazo[2,1-b]benzothiazole; Cyclic pifithrin-α-p-nitro |
Molecular Formula | C15H13N3O2S |
Purity | ≥95% |
Target | MDM-2/p53 |
Solubility | Soluble in DMSO |
Storage | Store at -20°C |
IUPAC Name | 2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole |
InChI | InChI=1S/C15H13N3O2S/c19-18(20)11-7-5-10(6-8-11)12-9-17-13-3-1-2-4-14(13)21-15(17)16-12/h5-9H,1-4H2 |
InChIKey | XMFNSEDROOHGBY-UHFFFAOYSA-N |
SMILES | C1CCC2=C(C1)N3C=C(N=C3S2)C4=CC=C(C=C4)[N+](=O)[O-] |