p-SCN-Bn-deferoxamine

• CAT Number: I040701
• CAS Number: 1222468-90-7
• Molecular Formula: C33H52N8O8S2
• Molecular Weight: 752.94
• Purity: ≥95%
• Synonyms: N-[5-[acetyl(hydroxy)amino]pentyl]-N’-hydroxy-N’-[5-[[4-[hydroxy-[5-[(4-isothiocyanatophenyl)carbamothioylamino]pentyl]amino]-4-oxobutanoyl]amino]pentyl]butanediamide
• IUPAC Name: N-[5-[acetyl(hydroxy)amino]pentyl]-N'-hydroxy-N'-[5-[[4-[hydroxy-[5-[(4-isothiocyanatophenyl)carbamothioylamino]pentyl]amino]-4-oxobutanoyl]amino]pentyl]butanediamide
• InChI: InChI=1S/C33H52N8O8S2/c1-26(42)39(47)22-8-2-5-19-34-29(43)15-17-31(45)40(48)23-9-3-6-20-35-30(44)16-18-32(46)41(49)24-10-4-7-21-36-33(51)38-28-13-11-27(12-14-28)37-25-50/h11-14,47-49H,2-10,15-24H2,1H3,(H,34,43)(H,35,44)(H2,36,38,51)
• InChIKey: HBAYEVATSBINBX-UHFFFAOYSA-N
• SMILES: CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=S)NC1=CC=C(C=C1)N=C=S)O)O)O

p-SCN-Bn-deferoxamine(CAT: I040701) is a bifunctional chelator widely used in radiopharmaceutical development, particularly for labeling biomolecules with zirconium-89 (⁸⁹Zr) for PET imaging. It combines deferoxamine (DFO), a high-affinity iron chelator, with a para-isothiocyanatobenzyl (p-SCN-Bn) functional group, enabling stable covalent conjugation to antibodies, peptides, or other amine-containing biomolecules. This chelator is essential in creating ⁸⁹Zr-labeled immuno-PET tracers, offering excellent in vivo stability, tumor-targeting capability, and imaging resolution. p-SCN-Bn-deferoxamine is widely used in oncology research and diagnostic imaging, facilitating the non-invasive tracking of biological processes, antibody biodistribution, and personalized treatment strategies in cancer and other diseases.