P2Y1/P2Y12 antagonist-1

• CAT Number: I040128
• CAS Number: 2738381-94-5
• Molecular Formula: C22H18N4O3
• Molecular Weight: 386.40
• Purity: ≥95%
• Synonyms: ethyl 2-(3-cyanophenyl)-3-[(4-cyanophenyl)methoxy]-5-methylimidazole-4-carboxylate
• InChI: InChI=1S/C22H18N4O3/c1-3-28-22(27)20-15(2)25-21(19-6-4-5-18(11-19)13-24)26(20)29-14-17-9-7-16(12-23)8-10-17/h4-11H,3,14H2,1-2H3
• InChIKey: AQVZLXOFKCFLKL-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C(N=C(N1OCC2=CC=C(C=C2)C#N)C3=CC=CC(=C3)C#N)C

P2Y1/P2Y12 antagonist-1 (Cat No.: I040128) is a small-molecule compound designed to block the P2Y1 and P2Y12 receptors, which are involved in platelet aggregation and various other cellular processes. These receptors are part of the purinergic signaling system and play key roles in thrombosis, inflammation, and vascular function. By inhibiting both P2Y1 and P2Y12, this antagonist may be useful in preventing blood clot formation and reducing the risk of cardiovascular events such as stroke and myocardial infarction, while potentially modulating inflammatory pathways.

Reference

[1]. Lei Y, et al. Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y1 and P2Y12 as an Oral Antiplatelet Agent with a Wider Therapeutic Window in Rats than Ticagrelor. J Med Chem. 2020 Dec 24;63(24):15752-15772.
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