P2Y2R/GPR17 antagonist 1

• CAT Number: I043679
• CAS Number: 2395016-49-4
• Molecular Formula: C19H13ClN2O6S
• Molecular Weight: 432.83
• Purity: ≥95%
• Synonyms: (3-nitrophenyl) 4-[(2-chlorobenzoyl)amino]benzenesulfonate
• InChI: InChI=1S/C19H13ClN2O6S/c20-18-7-2-1-6-17(18)19(23)21-13-8-10-16(11-9-13)29(26,27)28-15-5-3-4-14(12-15)22(24)25/h1-12H,(H,21,23)
• InChIKey: YGSIMJKEUKTDFX-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)OC3=CC=CC(=C3)[N+](=O)[O-])Cl

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes[1].

Reference

[1]. Pillaiyar T, et al. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur J Med Chem. 2020 Jan 15;186:111789.
 [Content Brief]