p38α inhibitor 1

• CAT Number: I019450
• CAS Number: 1034189-82-6
• Molecular Formula: C₂₂H₂₆F₂N₄O₂
• Molecular Weight: 416.46
• Purity: ≥95%
• Target: p38 MAPK; Autophagy
• Storage: Store at -20°C
• IUPAC Name: 5-(2,4-difluorophenoxy)-N-[2-(dimethylamino)ethyl]-1-(2-methylpropyl)indazole-6-carboxamide
• InChI: InChI=1S/C22H26F2N4O2/c1-14(2)13-28-19-11-17(22(29)25-7-8-27(3)4)21(9-15(19)12-26-28)30-20-6-5-16(23)10-18(20)24/h5-6,9-12,14H,7-8,13H2,1-4H3,(H,25,29)
• InChIKey: IFGWYHGYNVGVRB-UHFFFAOYSA-N
• SMILES: CC(C)CN1C2=CC(=C(C=C2C=N1)OC3=C(C=C(C=C3)F)F)C(=O)NCCN(C)C

p38α inhibitor 1（Cat No.:I019450）is a highly selective and potent inhibitor of the p38α isoform of MAPK, a kinase involved in regulating inflammatory and stress responses in cells. By inhibiting p38α, this compound reduces the production of pro-inflammatory cytokines such as TNF-α and IL-6, making it a valuable tool in research on inflammation-related diseases like rheumatoid arthritis, inflammatory bowel disease, and autoimmune disorders. It is used to explore the therapeutic potential of targeting p38α in various conditions, including cancer, cardiovascular diseases, and neurodegenerative disorders.

Reference

[1]. Baker W, et al. Monophosphates as mutual prodrugs of anti-inflammatory signal transduction modulators (aistm’s) and β-agonists for the treatment of pulmonary inflammation and bronchoconstriction. WO 2008076265 A1.