p38 MAPK-IN-1

• CAT Number: I000095
• CAS Number: 1006378-90-0
• Molecular Formula: C21H14F2N2O
• Molecular Weight: 348.35
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 4-(2,4-difluorophenyl)-8-(2-methylphenyl)-7-oxido-1,7-naphthyridin-7-ium
• InChI: InChI=1S/C21H14F2N2O/c1-13-4-2-3-5-15(13)21-20-18(9-11-25(21)26)16(8-10-24-20)17-7-6-14(22)12-19(17)23/h2-12H,1H3
• InChIKey: BSZQSLWNMVTKJT-UHFFFAOYSA-N
• SMILES: CC1=CC=CC=C1C2=[N+](C=CC3=C(C=CN=C32)C4=C(C=C(C=C4)F)F)[O-]

p38 MAPK-IN-1（Cat No.:I000095）is a potent and selective inhibitor of p38 mitogen-activated protein kinase (MAPK), which plays a critical role in cellular responses to stress, inflammation, and immune signaling. This compound is widely used in research to study the modulation of the p38 MAPK pathway, which is implicated in various diseases such as cancer, autoimmune disorders, and neurodegenerative conditions. By inhibiting p38 MAPK, p38 MAPK-IN-1 helps researchers explore the therapeutic potential of targeting this pathway for the treatment of inflammation-driven diseases and cancer. Its specificity makes it a valuable tool in biochemical research.

Reference

[1]. Lumeras W, et al. 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem. 2011 Nov 24;54(22):7899-910.