For research use only. Not for therapeutic Use.
p53 and MDM2 proteins-interaction-inhibitor (chiral) (Cat.No:I005584) is an inhibitor of the interaction between p53 and MDM2 proteins.These inhibitors block this interaction, thereby stabilizing p53 and restoring its function in controlling cell growth and inducing apoptosis, especially in cancer cells. The chiral nature of these compounds allows for selective and more potent binding, offering a promising therapeutic strategy to treat cancers with mutated or dysfunctional p53.
| CAS Number | 939981-37-0 |
| Synonyms | 2-[4-[(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazole-1-carbonyl]piperazin-1-yl]-1-morpholin-4-ylethanone |
| Molecular Formula | C40H49Cl2N5O4 |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 2-[4-[(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazole-1-carbonyl]piperazin-1-yl]-1-morpholin-4-ylethanone |
| InChI | 1S/C40H49Cl2N5O4/c1-7-51-34-26-30(38(2,3)4)12-17-33(34)36-43-39(5,28-8-13-31(41)14-9-28)40(6,29-10-15-32(42)16-11-29)47(36)37(49)46-20-18-44(19-21-46)27-35(48)45-22-24-50-25-23-45/h8-17,26H,7,18-25,27H2,1-6H3/t39-,40+/m0/s1 |
| InChIKey | DJZBZZRLUQDRII-IOLBBIBUSA-N |
| SMILES | CCOC1=C(C=CC(=C1)C(C)(C)C)C2=N[C@@]([C@@](N2C(=O)N3CCN(CC3)CC(=O)N4CCOCC4)(C)C5=CC=C(C=C5)Cl)(C)C6=CC=C(C=C6)Cl |
