P62-mediated mitophagy inducer

• CAT Number: I018168
• CAS Number: 1809031-84-2
• Molecular Formula: C₁₄H₉IN₄O₂
• Molecular Weight: 392.15
• Purity: ≥95%
• Target: p62
• Storage: Store at -20°C
• IUPAC Name: 1-(3-iodophenyl)-4-(3-nitrophenyl)triazole
• InChI: InChI=1S/C14H9IN4O2/c15-11-4-2-5-12(8-11)18-9-14(16-17-18)10-3-1-6-13(7-10)19(20)21/h1-9H
• InChIKey: LSVWEYNSNZJEGB-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)[N+](=O)[O-])C2=CN(N=N2)C3=CC(=CC=C3)I

The P62-mediated mitophagy inducer （Cat No.:I018168）is a small molecule compound that activates the P62-mediated pathway of mitophagy, without the need for Parkin recruitment or depolarization of the mitochondrial membrane potential. It remains active in cells with impaired PINK1/Parkin pathway, which is often associated with neurodegenerative diseases. However, further research is needed to evaluate its safety and efficacy for clinical use.

Reference

[1]. East DA, et al. PMI: a ΔΨm independent pharmacological regulator of mitophagy. Chem Biol. 2014 Nov 20;21(11):1585-96.