For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>P7C3 is a NAMPT activator. P7C3 can enhance learning and memory in aged rats. Protects newborn neurons in the dentate gyrus by mitigating cell death.<br>In vitro: Administration of active P7C3 chemicals to cells treated with doxorubicin, which induces NAD depletion, led to a rebound in intracellular levels of NAD and concomitant protection from doxorubicin-mediated toxicity.<br>In vivo: P7C3 is orally bioavailable, crosses the blood-brain barrier, and is non-toxic at doses several fold higher than the efficacious dose.An easily administered pro-neurogenic compound. The administration of P7C3 is 10mg/ kg( IP) in rats. Administration of P7C3 to normal mice, as well as npas3-/- mice, enhance survival of neurons subsequent to their birth in the SGZ.<br></p>
| Catalog Number | I003051 |
| CAS Number | 301353-96-8 |
| Synonyms | 3,6-dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol |
| Molecular Formula | C21H18Br2N2O |
| Purity | ≥95% |
| Solubility | DMSO ≥ 33 mg/mL |
| Storage | -20°C |
| InChI | InChI=1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2 |
| InChIKey | FZHHRERIIVOATI-UHFFFAOYSA-N |
| SMILES | BrC(C=C1)=CC2=C1N(CC(CNC3=CC=CC=C3)O)C4=CC=C(Br)C=C42 |
| Reference | </br>1:Corrigendum to /The neuroprotective compound P7C3-A20 promotes neurogenesis and improves cognitive function after stroke/ [Exp. Neurol. 290 (2017) 63-73]. Loris ZB, Pieper AA, Dietrich WD.Exp Neurol. 2017 May 13. pii: S0014-4886(17)30109-7. doi: 10.1016/j.expneurol.2017.04.016. [Epub ahead of print] No abstract available. PMID: 28511786 </br>2:The neuroprotective compound P7C3-A20 promotes neurogenesis and improves cognitive function after ischemic stroke. Loris ZB, Pieper AA, Dalton Dietrich W.Exp Neurol. 2017 Apr;290:63-73. doi: 10.1016/j.expneurol.2017.01.006. Epub 2017 Jan 8. PMID: 28077334 </br>3:Protective effect of P7C3 on retinal ganglion cells from optic nerve injury. Oku H, Morishita S, Horie T, Nishikawa Y, Kida T, Mimura M, Kojima S, Ikeda T.Jpn J Ophthalmol. 2017 Mar;61(2):195-203. doi: 10.1007/s10384-016-0493-6. Epub 2016 Dec 28. PMID: 28032230 </br>4:Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke. Wang SN, Xu TY, Wang X, Guan YF, Zhang SL, Wang P, Miao CY.CNS Neurosci Ther. 2016 Sep;22(9):782-8. doi: 10.1111/cns.12576. Epub 2016 Jun 23. PMID: 27333812 </br>5:P7C3 Attenuates the Scopolamine-Induced Memory Impairments in C57BL/6J Mice. Jiang B, Song L, Huang C, Zhang W.Neurochem Res. 2016 May;41(5):1010-9. doi: 10.1007/s11064-015-1783-y. Epub 2015 Dec 8. PMID: 26646000 </br>6:Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome [Corrected]. Latchney SE, Jaramillo TC, Rivera PD, Eisch AJ, Powell CM.Neurosci Lett. 2015 Mar 30;591:86-92. doi: 10.1016/j.neulet.2015.02.008. Epub 2015 Feb 7. Erratum in: Neurosci Lett. 2015 Jun 15;597():25. PMID: 25668489 Free PMC Article</br>7:Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson/’s disease. De Jesús-Cortés H, Miller AD, Britt JK, DeMarco AJ, De Jesús-Cortés M, Stuebing E, Naidoo J, Vázquez-Rosa E, Morlock L, Williams NS, Ready JM, Narayanan NS, Pieper AA.NPJ Parkinsons Dis. 2015;1. pii: 15010. Epub 2015 May 21. PMID: 27158662 Free PMC Article</br>8:Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243. Dutca LM, Stasheff SF, Hedberg-Buenz A, Rudd DS, Batra N, Blodi FR, Yorek MS, Yin T, Shankar M, Herlein JA, Naidoo J, Morlock L, Williams N, Kardon RH, Anderson MG, Pieper AA, Harper MM.Invest Ophthalmol Vis Sci. 2014 Dec 2;55(12):8330-41. doi: 10.1167/iovs.14-15468. PMID: 25468886 Free PMC Article</br>9:Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury. Kemp SW, Szynkaruk M, Stanoulis KN, Wood MD, Liu EH, Willand MP, Morlock L, Naidoo J, Williams NS, Ready JM, Mangano TJ, Beggs S, Salter MW, Gordon T, Pieper AA, Borschel GH.Neuroscience. 2015 Jan 22;284:202-16. doi: 10.1016/j.neuroscience.2014.10.005. Epub 2014 Oct 13. PMID: 25313000 </br>10:P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury. Yin TC, Britt JK, De Jesús-Cortés H, Lu Y, Genova RM, Khan MZ, Voorhees JR, Shao J, Katzman AC, Huntington PJ, Wassink C, McDaniel L, Newell EA, Dutca LM, Naidoo J, Cui H, Bassuk AG, Harper MM, McKnight SL, Ready JM, Pieper AA.Cell Rep. 2014 Sep 25;8(6):1731-40. doi: 10.1016/j.celrep.2014.08.030. Epub 2014 Sep 15. PMID: 25220467 Free PMC Article |
