PA-824

• CAT Number: I002421
• CAS Number: 187235-37-6
• Molecular Formula: C14H12F3N3O5
• Molecular Weight: 359.26
• Purity: 98%
• Synonyms: Pretomanid
• Target: Bacterial
• Target Protein: P95029,P9WJY5
• Solubility: DMSO: ≥ 34 mg/mL
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• IC50: 0.015 to 0.25 ug/ml (MICs)
• IUPAC Name: (6S)-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• InChI: InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
• InChIKey: ZLHZLMOSPGACSZ-NSHDSACASA-N
• SMILES: C1[C@@H](COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F

PA-824（Cat No.:I002421）is an investigational nitroimidazo-oxazine compound developed for the treatment of tuberculosis (TB), including multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). It functions through a dual mechanism: inhibiting mycolic acid synthesis, essential for bacterial cell walls, and generating reactive nitrogen species that damage bacterial DNA. PA-824 has shown potent bactericidal activity against both active and dormant Mycobacterium tuberculosis. Its ability to shorten treatment duration and its efficacy in drug-resistant TB strains make PA-824 a promising candidate in the global fight against tuberculosis.