For research use only. Not for therapeutic Use.
PA(β)N Dihydrochloride (Cat No.:I013635) is a potent efflux pump inhibitor primarily used in microbiology and antibiotic research. It functions by inhibiting multidrug efflux pumps, specifically in Gram-negative bacteria, thus enhancing the efficacy of antibiotics that are often expelled by these pumps. PA(β)N dihydrochloride is valuable in studies aimed at overcoming antibiotic resistance, as it allows antibiotics to remain within bacterial cells longer, increasing their bactericidal effects. This compound is widely utilized in research to explore new combination therapies against resistant bacterial strains.
| Catalog Number | I013635 |
| CAS Number | 100929-99-5 |
| Molecular Formula | C₂₅H₃₂Cl₂N₆O₂ |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | DMSO: ≥ 100 mg/mL |
| IUPAC Name | (2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)-N-naphthalen-2-ylpentanamide;dihydrochloride |
| InChI | InChI=1S/C25H30N6O2.2ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);2*1H/t21-,22-;;/m0../s1 |
| InChIKey | MRUMOHLDHMZGMS-IXOXMDGESA-N |
| SMILES | C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC2=CC3=CC=CC=C3C=C2)N.Cl.Cl |
| Reference | [1]. Lomovskaya O, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother. 2001 Jan;45(1):105-16.<br>[2]. Kurinčič M, et al. Effects of efflux pump inhibitors on erythromycin, ciprofloxacin, and tetracycline resistance in Campylobacter spp. isolates. Microb Drug Resist. 2012 Oct;18(5):492-501. <br>[3]. Lamers RP, et al. The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria. PLoS One. 2013;8(3):e60666. |
