PA3552-IN-1

• CAT Number: I043708
• CAS Number: 1008121-12-7
• Molecular Formula: C13H8ClFN2O4
• Molecular Weight: 310.67
• Purity: ≥95%
• Synonyms: N-(2-chloro-4-nitrophenyl)-5-fluoro-2-hydroxybenzamide
• InChI: InChI=1S/C13H8ClFN2O4/c14-10-6-8(17(20)21)2-3-11(10)16-13(19)9-5-7(15)1-4-12(9)18/h1-6,18H,(H,16,19)
• InChIKey: BDYVQNWGUDCTIB-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)F)O

PA3552-IN-1 (compound 15) is an antibiotic adjuvant that restores sensitivity of MDR P. aeruginosa DK2 strain to Polymyxin B. PA3552-IN-1 can reduce PA3552 expression[1].

Reference

[1]. Lu T, et, al. Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2. Eur J Med Chem. 2022 Jun 5;236:114318.
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