For research use only. Not for therapeutic Use.
PAC 14028(CAT: I008538) is described as a vanilloid VR1 receptor (TRPV1) antagonist. The transient receptor potential vanilloid 1 (TRPV1) receptor is involved in the perception of pain, as well as itch and inflammation. By acting as an antagonist of the TRPV1 receptor, PAC 14028 may have the potential to reduce itching (pruritus) and alleviate symptoms associated with conditions such as pruritus and acne. However, it’s important to note that further research and development would be necessary to fully understand its therapeutic applications and assess its efficacy and safety.
| Catalog Number | I008538 |
| CAS Number | 1005168-10-4 |
| Synonyms | PAC 14028; PAC-14028; PAC14028;(R,E)-N-(1-(3,5-difluoro-4-(methylsulfonamido)phenyl)ethyl)-3-(2-propyl-6-(trifluoromethyl)pyridin-3-yl)acrylamide |
| Molecular Formula | C21H22F5N3O3S |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (E)-N-[(1R)-1-[3,5-difluoro-4-(methanesulfonamido)phenyl]ethyl]-3-[2-propyl-6-(trifluoromethyl)pyridin-3-yl]prop-2-enamide |
| InChI | InChI=1S/C21H22F5N3O3S/c1-4-5-17-13(6-8-18(28-17)21(24,25)26)7-9-19(30)27-12(2)14-10-15(22)20(16(23)11-14)29-33(3,31)32/h6-12,29H,4-5H2,1-3H3,(H,27,30)/b9-7+/t12-/m1/s1 |
| InChIKey | UKGJZDSUJSPAJL-YPUOHESYSA-N |
| SMILES | O=C(N[C@@H](C1=CC(F)=C(NS(=O)(C)=O)C(F)=C1)C)/C=C/C2=CC=C(C(F)(F)F)N=C2CCC |
| Reference | <br /> |
