Paclitaxel

• CAT Number: A000813
• CAS Number: 33069-62-4
• Molecular Formula: C₄₇H₅₁NO₁₄
• Molecular Weight: 853.92
• Purity: ≥95%
• Synonyms: TAXOL; Taxol A; 33069-62-4; Abraxane; Paxene
• Target: Microtubule/Tubulin
• Solubility: >42.7mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
• InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
• InChIKey: RCINICONZNJXQF-MZXODVADSA-N
• SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

Paclitaxel（Cat No.:A000813）is a widely used chemotherapeutic agent derived from the bark of the Pacific yew tree, known for its potent antitumor properties. It functions by stabilizing microtubules and preventing their depolymerization, thereby disrupting the normal cell cycle and inducing apoptosis in rapidly dividing cancer cells. Paclitaxel is effective against various malignancies, including breast, ovarian, and lung cancers. Despite its effectiveness, it is associated with side effects such as myelosuppression, neuropathy, and hypersensitivity reactions. Ongoing research seeks to enhance its efficacy and reduce toxicity through improved formulation and combination therapies.

Reference

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