For research use only. Not for therapeutic Use.
Paclitaxel（Cat No.:A000813）is a widely used chemotherapeutic agent derived from the bark of the Pacific yew tree, known for its potent antitumor properties. It functions by stabilizing microtubules and preventing their depolymerization, thereby disrupting the normal cell cycle and inducing apoptosis in rapidly dividing cancer cells. Paclitaxel is effective against various malignancies, including breast, ovarian, and lung cancers. Despite its effectiveness, it is associated with side effects such as myelosuppression, neuropathy, and hypersensitivity reactions. Ongoing research seeks to enhance its efficacy and reduce toxicity through improved formulation and combination therapies.
| Catalog Number | A000813 |
| CAS Number | 33069-62-4 |
| Synonyms | TAXOL; Taxol A; 33069-62-4; Abraxane; Paxene |
| Molecular Formula | C₄₇H₅₁NO₁₄ |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| Solubility | >42.7mg/mL in DMSO |
| Storage | -20°C |
| IUPAC Name | [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate |
| InChI | InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1 |
| InChIKey | RCINICONZNJXQF-MZXODVADSA-N |
| SMILES | CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C |
| Reference | 1: Van Cutsem E, Bang YJ, Mansoor W, Petty RD, Chao Y, Cunningham D, Ferry DR, Smith NR, Frewer P, Ratnayake J, Stockman PK, Kilgour E, Landers D. A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplification. Ann Oncol. 2017 Jun 1;28(6):1316-1324. doi: 10.1093/annonc/mdx107. PubMed PMID: 29177434.<br /> |
