PAK4-IN-1

• CAT Number: I002149
• CAS Number: 1643913-93-2
• Molecular Formula: C35H29F3N4O3
• Molecular Weight: 610.6
• Purity: ≥95%
• Synonyms: (1Z,2E)-3-(6-aminopyridin-2-yl)-N-((5-(4-(4,4-difluoropiperidine-1-carbonyl)phenyl)-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylimidic acid
• Target: Cytoskeleton
• Solubility: DMSO: ≥ 43 mg/mL
• Storage: Store at -20°C
• IC50: ≤100 nM (in MTT assay)
• InChI: InChI=1S/C35H29F3N4O3/c36-27-10-8-23(9-11-27)30-20-25(22-4-6-24(7-5-22)34(44)42-16-14-35(37,38)15-17-42)18-26-19-29(45-33(26)30)21-40-32(43)13-12-28-2-1-3-31(39)41-28/h1-13,18-20H,14-17,21H2,(H2,39,41)(H,40,43)/b13-12+
• InChIKey: MRFOPLWJZULAQD-SWGQDTFXSA-N
• SMILES: FC(C=C1)=CC=C1C2=C(OC(CNC(/C=C/C3=CC=C(N)N=C3)=O)=C4)C4=CC(C5=CC=C(C(N6CCC(F)(F)CC6)=O)C=C5)=C2

PAK4-IN-1 (Cat.No:I002149) is a small molecule inhibitor that targets P21-activated kinase 4 (PAK4), a protein involved in cell signaling pathways. PAK4-IN-1 has shown potential in preclinical studies for its ability to suppress tumor growth, migration, and invasion in various cancer types. Further research is ongoing to explore its therapeutic applications in cancer treatment.

Reference

[1]. Baloglu Erkan; et al. Substituted benzofuranyl and benzoxazolyl compounds as PAK modulators and their preparation. From PCT Int. Appl. (2015), WO 2015003166 A1 20150108.