Palbociclib-d8

• CAT Number: R060402
• CAS Number: 1628752-83-9
• Molecular Formula: C24H29N7O2
• Molecular Weight: 455.592
• Purity: ≥95%
• Synonyms: 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one-d8; PD 0332991-d8; PD 332991-d8
• Target: CDK
• Storage: Store at RT
• IUPAC Name: 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl)pyridin-2-yl]amino]pyrido[2,3-d]pyrimidin-7-one
• InChI: InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)/i9D2,10D2,11D2,12D2
• InChIKey: AHJRHEGDXFFMBM-PMCMNDOISA-N
• SMILES: [2H]C1(C(N(C(C(N1)([2H])[2H])([2H])[2H])C2=CN=C(C=C2)NC3=NC=C4C(=C(C(=O)N(C4=N3)C5CCCC5)C(=O)C)C)([2H])[2H])[2H]

Palbociclib-d8 is a deuterated form of palbociclib, featuring eight deuterium atoms incorporated into its molecular structure. This high-purity isotopically labeled compound is crucial for advanced research in oncology, pharmacology, and drug metabolism. Palbociclib-d8 is particularly valuable for studying the metabolic pathways, pharmacokinetics, and therapeutic efficacy of palbociclib, a selective cyclin-dependent kinase 4/6 (CDK4/6) inhibitor used in the treatment of hormone receptor-positive breast cancer. The deuterium labeling allows for precise tracking and quantification in biological systems using mass spectrometry, enhancing the accuracy of studies on drug absorption, distribution, metabolism, and excretion. This compound is a critical tool for researchers focused on optimizing cancer therapies, understanding drug interactions, and developing personalized medicine approaches for cancer treatment, providing reliable and consistent results in various experimental settings.