Palbociclib (PD-0332991) HCl

• CAT Number: I008545
• CAS Number: 827022-32-2
• Molecular Formula: C24H29N7O2.HCl
• Molecular Weight: 483.99
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl

Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.

Reference

[1] Fry DW, et al. Mol Cancer Ther, 2004, 3(11), 1427-1438.
[2] Menu E, et al. Cancer Res, 2008, 68(14), 5519-5523.
[3] Finn RS, et al. Breast Cancer Res, 2009, 11(5), R77.
[4] Katsumi Y, et al. Biochem Biophys Res Commun, 2011, 413(1), 62-68.