Paliperidone Palmitate

• CAT Number: R054433
• CAS Number: 199739-10-1
• Molecular Formula: C39H57FN4O4
• Molecular Weight: 664.907
• Purity: ≥95%
• Synonyms: 9-Hydroxyrisperidone Palmitate; Invega Sustenna; RO 92670; Hexadecanoic Acid 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl Ester
• Target: Neuronal Signaling
• Storage: Desiccate at RT
• IUPAC Name: [3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl] hexadecanoate
• InChI: InChI=1S/C39H57FN4O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-18-36(45)47-34-17-16-24-44-38(34)41-29(2)32(39(44)46)23-27-43-25-21-30(22-26-43)37-33-20-19-31(40)28-35(33)48-42-37/h19-20,28,30,34H,3-18,21-27H2,1-2H3
• InChIKey: VOMKSBFLAZZBOW-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCCCCCCC(=O)OC1CCCN2C1=NC(=C(C2=O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F)C

Paliperidone Palmitate (CAS 199739-10-1) is an impurity of Paliperidone which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class of medications. Intramuscular paliperidone palmitate is a long-acting, atypical antipsychotic that is indicated in the US for the acute and maintenance therapy of adult patients with schizophrenia.

Overview of Clinical Research

Paliperidone Palmitate is  a dopamine D2 receptor antagonist and a serotonin 2 receptor antagonist. It is preregistrated for Schizophrenia (Treatment-experienced) in European Union (IM).

Reference

1.Nussbaum, Abraham M., and T. Scott Stroup. "Paliperidone palmitate for schizophrenia." Cochrane Database of Systematic Reviews 6 (2012).
2.Hoy, Sheridan M., Lesley J. Scott, and Gillian M. Keating. "Intramuscular paliperidone palmitate." CNS drugs 24.3 (2010): 227-244.