Palonosetron HCl

• CAT Number: A000372
• CAS Number: 135729-62-3
• Molecular Formula: C19H24N2O • HCl
• Molecular Weight: 332.90
• Purity: 98%
• Synonyms: RS 25259, RS 25259 197
• Target: Neuronal Signaling
• Solubility: Limited solubility
• Appearance: Crystalline solid
• Storage: 3 years -20C powder
• IUPAC Name: (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one;hydrochloride
• InChI: InChI=1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1
• InChIKey: OLDRWYVIKMSFFB-SSPJITILSA-N
• SMILES: C1CC2CN(C(=O)C3=CC=CC(=C23)C1)C4CN5CCC4CC5.Cl

Palonosetron HCl（Cat No.:A000372）is a potent antiemetic medication used to prevent nausea and vomiting caused by chemotherapy and surgery. It is a selective serotonin 5-HT3 receptor antagonist that blocks serotonin’s action in the central nervous system and gastrointestinal tract. With a longer half-life and greater binding affinity compared to older 5-HT3 antagonists, Palonosetron provides extended protection against both acute and delayed chemotherapy-induced nausea and vomiting (CINV). Administered intravenously or orally, it is well-tolerated with minimal side effects, making it an essential component in supportive cancer care.