Paltusotine dihydrochloride

• CAT Number: I047719
• CAS Number: 2172875-40-8
• Molecular Formula: C27H22F2N4O.2HCl
• Molecular Weight: 529.41
• Purity: ≥95%
• IUPAC Name: 3-[4-(4-aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile
• InChI: InChI=1S/C27H22F2N4O/c28-19-10-18(11-20(29)13-19)24-15-32-25-5-4-16(22-3-1-2-17(14-30)27(22)34)12-23(25)26(24)33-8-6-21(31)7-9-33/h1-5,10-13,15,21,34H,6-9,31H2
• SMILES: C1CN(CCC1N)C2=C3C=C(C=CC3=NC=C2C4=CC(=CC(=C4)F)F)C5=CC=CC(=C5O)C#N

Paltusotine dihydrochloride is a potent, selective, and orally bioavailable non-peptide SST2 agonist with an EC50 value of 0.25 nM. Water-soluble salt form of Paltusotine.
Keywords: Paltusotine dihydrochloride | Supplier | SST2 agonist | CRN00808 | CRN 00808 | CRN-00808 | CAS [2172875-40-8] | [2172870-89-0] | [2361216-83-1] | Somatostatin | SST | Agonist | Receptors | Acromegaly | NET | Neuroendocrine tumor

Reference

J Zhao et al. Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist. ACS Med Chem Lett. 2022 Dec 10;14(1):66-74.