Pam2CSK4 TFA salt

• CAT Number: I034185
• Molecular Formula: C67H127F3N10O14S
• Molecular Weight: 1385.86
• Purity: 98%
• Synonyms: Pam2CSK4 TFA salt; Pam2-CSK4 TFA salt; Pam2 CSK4 TFA salt; Pam2Cys-Ser-(Lys)4
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: S-((R)-2,3-bis(palmitoyloxy)propyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine compound with 2,2,2-trifluoroacetic acid (1:1)
• InChI: InChI=1S/C65H126N10O12S.C2HF3O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-41-58(77)86-48-51(87-59(78)42-28-26-24-22-20-18-16-14-12-10-8-6-4-2)49-88-50-52(70)60(79)75-57(47-76)64(83)73-54(38-30-34-44-67)62(81)71-53(37-29-33-43-66)61(80)72-55(39-31-35-45-68)63(82)74-56(65(84)85)40-32-36-46-69;3-2(4,5)1(6)7/h51-57,76H,3-50,66-70H2,1-2H3,(H,71,81)(H,72,80)(H,73,83)(H,74,82)(H,75,79)(H,84,85);(H,6,7)/t51-,52+,53+,54+,55+,56+,57+;/m1./s1
• InChIKey: WUCKUXUWRPCGSL-WJRQQJDCSA-N
• SMILES: CCCCCCCCCCCCCCCC(OC[C@H](CSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CCCCN)=O)CCCCN)=O)CCCCN)=O)CO)=O)N)OC(CCCCCCCCCCCCCCC)=O)=O.OC(C(F)(F)F)=O

Pam2CSK4 TFA Salt(CAT: I034185) is a synthetic diacylated lipopeptide that serves as a potent agonist for Toll-like receptor 2/6 (TLR2/6) heterodimers. By activating TLR2/6, it triggers innate immune responses, including cytokine production and immune cell activation. This mechanism is particularly significant in the immunology and inflammation field, where it is used to study immune system modulation and inflammatory pathways. Pam2CSK4 TFA Salt is a critical tool for research into vaccine adjuvants, immune therapies, and the development of treatments for inflammatory and infectious diseases. Its high specificity makes it invaluable for advancing immunological research.