For research use only. Not for therapeutic Use.
Pamaquine naphthoate (Cat.No:I034189) is a synthetic antimalarial drug. It is a derivative of primaquine and is used in the treatment and prevention of malaria caused by Plasmodium vivax and Plasmodium ovale. Pamaquine naphthoate acts by killing the dormant liver-stage parasites, preventing relapses of the disease. It is an important tool in malaria control programs.
| Catalog Number | I034189 |
| CAS Number | 635-05-2 |
| Synonyms | Aminoquin naphthoate, Beprochine naphthoate, Gamefar naphthoate, Pamaquine embonate, Pamaquine naphthoate , Plasmoquine naphthoate |
| Molecular Formula | C42H45N3O7 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-Naphthoic acid, 4,4'-methylenebis(3-hydroxy-, compd. with 8-((4-(diethylamino)-1-methylbutyl)amino)-6-methoxyquinoline (1:1) |
| InChI | 1S/C23H16O6.C19H29N3O/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-5-22(6-2)12-8-9-15(3)21-18-14-17(23-4)13-16-10-7-11-20-19(16)18/h1-10,24-25H,11H2,(H,26,27)(H,28,29);7,10-11,13-15,21H,5-6,8-9,12H2,1-4H3 |
| InChIKey | IPPMKVWUPMOGFL-UHFFFAOYSA-N |
| SMILES | c1(c2c(cc(C(O)=O)c1O)cccc2)Cc1c2c(cc(c1O)C(O)=O)cccc2.c1(c2c(cc(c1)OC)cccn2)N[C@@H](CCCN(CC)CC)C |
| Reference | 1: Sweeney AW, Blackburn CR, Rieckmann KH. Short report: the activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains). Am J Trop Med Hyg. 2004 Aug;71(2):187-9. PubMed PMID: 15306708. |
