Pamufetinib (TAS-115)

• CAT Number: I009712
• CAS Number: 1190836-34-0
• Molecular Formula: C27H23FN4O4S
• Molecular Weight: 518.56
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CNC(=O)C1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3)NC(=S)NC(=O)CC4=CC=CC=C4)F

Pamufetinib (TAS-115) is a highly potent c-Met and VEGFR dual inhibitor with IC50s of 30 nM and 32 nM for recombinant VEGFR2 and recombinant MET, respectively.

Reference

[1] Hidenori Fujita, et, al. Mol Cancer Ther. 2013 Dec;12(12):2685-96.