For research use only. Not for therapeutic Use.
Pan KRas-IN-1（Cat No.:I042891）is a potent pan-KRas inhibitor targeting multiple KRas mutant isoforms, including G12D, G12S, G12C, G12V, and G13D, with IC₅₀ values ranging from 6 to 32 nM. By inhibiting KRas-driven signaling pathways, Pan KRas-IN-1 effectively suppresses the phosphorylation of ERK, a downstream effector, across various cancer cell lines harboring KRas mutations. Notably, it exhibits anti-proliferative activity against mutations resistant to KRas G12C inhibitors like Adagrasib, particularly in mouse 3T3 fibroblasts with mutations such as G12A, G12C, G12D, G12V, and Q61H. This broad-spectrum inhibition underscores its potential as a therapeutic agent in cancers driven by diverse KRas mutations.
| CAS Number | 2791263-84-6 |
| Synonyms | (3R)-1-[7-(8-ethyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoro-2-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]-3-methylpiperidin-3-ol |
| Molecular Formula | C33H36F3N5O3 |
| Purity | ≥95% |
| IUPAC Name | (3R)-1-[7-(8-ethyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoro-2-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]-3-methylpiperidin-3-ol |
| InChI | InChI=1S/C33H36F3N5O3/c1-3-22-25(35)7-6-19-12-21(42)13-23(26(19)22)28-27(36)29-24(15-37-28)30(40-10-4-8-32(2,43)17-40)39-31(38-29)44-18-33-9-5-11-41(33)16-20(34)14-33/h6-7,12-13,15,20,42-43H,3-5,8-11,14,16-18H2,1-2H3/t20-,32-,33+/m1/s1 |
| InChIKey | RZYWNBKMTZABBP-PAXFXPPDSA-N |
| SMILES | CCC1=C(C=CC2=CC(=CC(=C21)C3=NC=C4C(=C3F)N=C(N=C4N5CCC[C@@](C5)(C)O)OC[C@@]67CCCN6C[C@@H](C7)F)O)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
