For research use only. Not for therapeutic Use.
Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent[1].
Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex[1].
| Catalog Number | I045828 |
| CAS Number | 139225-22-2 |
| Synonyms | (5S)-5-[[4-(1,3-benzodioxol-5-yl)-4-hydroxypiperidin-1-yl]methyl]-3-(4-methoxyphenyl)-1,3-oxazolidin-2-one |
| Molecular Formula | C23H26N2O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H26N2O6/c1-28-18-5-3-17(4-6-18)25-14-19(31-22(25)26)13-24-10-8-23(27,9-11-24)16-2-7-20-21(12-16)30-15-29-20/h2-7,12,19,27H,8-11,13-15H2,1H3/t19-/m0/s1 |
| InChIKey | NINYZUDVKTUKIA-IBGZPJMESA-N |
| SMILES | COC1=CC=C(C=C1)N2CC(OC2=O)CN3CCC(CC3)(C4=CC5=C(C=C4)OCO5)O |
| Reference | [1]. N Dahmen, et al. Induction of C-Fos Gene Expression by the Selective Sigma Receptor Ligand EMD 57445 in Rat Brain. Eur Neuropsychopharmacol. 1996 Aug;6(3):237-43. |
