Pancuronium Bromide

• CAT Number: A000361
• CAS Number: 15500-66-0
• Molecular Formula: C35H60Br2N2O4
• Molecular Weight: 732.67
• Purity: ≥95%
• Synonyms: Pavulon; Pancuronium dibromide; Mioblock; 15500-66-0; Pancuronii bromidum
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• IUPAC Name: [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;dibromide
• InChI: InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1
• InChIKey: NPIJXCQZLFKBMV-YTGGZNJNSA-L
• SMILES: CC(=O)OC1CC2CCC3C(C2(CC1[N+]4(CCCCC4)C)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]

Pancuronium Bromide (CAS 15500-66-0), also known as Pavulon and NA-97, is a bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent, Pancuronium bromide is more potent than curare but has less effect on the circulatory system and on histamine release.

Reference

1: Zayed SI. Flow injection potentiometric determination of pancuronium bromide in pharmaceutical preparation and urine samples using modified carbon paste electrodes. Chem Pharm Bull (Tokyo). 2011;59(2):254-9. PubMed PMID: 21297308.
2: Stankov-Jovanovic VP, Nikolic-Mandic SD, Mandic LjM, Mitic VD. A modification of the kinetic determination of pancuronium bromide based on its inhibitory effect on cholinesterase. J Clin Lab Anal. 2007;21(2):124-31. PubMed PMID: 17385680.
3: Stankov-Jovanović VP, Nikolić-Mandić SD, Mandić LM, Mitić VD. Cholinesterase inhibition based determination of pancuronium bromide in biological samples. Anal Bioanal Chem. 2006 Aug;385(8):1462-9. Epub 2006 Jun 28. PubMed PMID: 16804673.
4: Andresen BD, Alcaraz A, Grant PM. The application of pancuronium bromide (Pavulon) forensic analyses to tissue samples from an /Angel of Death/ investigation. J Forensic Sci. 2005 Jan;50(1):215-9. PubMed PMID: 15831022.
5: Andresen BD, Alcaraz A, Grant PM. Pancuronium bromide (Pavulon) isolation and identification in aged autopsy tissues and fluids. J Forensic Sci. 2005 Jan;50(1):196-203. PubMed PMID: 15831019.
6: Oransky I. Who–and how–to kill are focus of US death penalty cases. Questions about prisoners/' mental competence and use of pancuronium bromide ignite recent controversy. Lancet. 2003 Oct 18;362(9392):1287. PubMed PMID: 14577434.
7: Delogu G, Moretti S, Marcellini S, Antonucci A, Tellan G, Marandola M, Signore M, Famularo G. Pancuronium bromide, a non-depolarizing muscle relaxant which promotes apoptosis of blood lymphocytes in vitro. Acta Anaesthesiol Scand. 2003 Oct;47(9):1138-44. PubMed PMID: 12969109.
8: Sullivan TC, Hellyer PW, Lee DD, Davidson MG. Respiratory function and extraocular muscle paralysis following administration of pancuronium bromide in dogs. Vet Ophthalmol. 1998;1(2-3):125-128. PubMed PMID: 11397221.
9: Koishi K, Ooe Y, Hirata A, Kimura H, Izawa M. [Respiratory muscle weakness after prolonged use of hydrocortisone and pancuronium bromide]. Masui. 2000 Jan;49(1):72-4. Japanese. PubMed PMID: 10689850.
10: Cheung PY, Tyebkhan JM, Peliowski A, Ainsworth W, Robertson CM. Prolonged use of pancuronium bromide and sensorineural hearing loss in childhood survivors of congenital diaphragmatic hernia. J Pediatr. 1999 Aug;135(2 Pt 1):233-9. PubMed PMID: 10431119.