PANMe

• CAT Number: I034200
• Molecular Formula: C25H30O4
• Molecular Weight: 394.51
• Purity: 98%
• Synonyms: PANMe
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (2Z,4E)-5-((1S,4S)-1-Hydroxy-2,6,6-trimethyl-4-((3-(p-tolyl)prop-2-yn-1-yl)oxy)cyclohex-2-en-1-yl)-3-methylpenta-2,4-dienoic acid
• InChI: InChI=1S/C25H30O4/c1-18-8-10-21(11-9-18)7-6-14-29-22-16-20(3)25(28,24(4,5)17-22)13-12-19(2)15-23(26)27/h8-13,15-16,22,28H,14,17H2,1-5H3,(H,26,27)/b13-12+,19-15-/t22-,25-/m1/s1
• InChIKey: WPPIXXDTHHCJMC-CRNWAGJPSA-N
• SMILES: O=C(O)/C=C(C)C=C[C@@]1(O)C(C)=C[C@@H](OCC#CC2=CC=C(C)C=C2)CC1(C)C

PANMe (Cat No.: I034200) is a stable analog of pantothenic acid (vitamin B5) designed to resist degradation by pantetheinase. It serves as a prodrug that can be metabolized into Coenzyme A (CoA) analogs, supporting cellular metabolism and energy production. PANMe is studied for its potential in antimicrobial and metabolic disorder applications, as it may disrupt bacterial CoA biosynthesis. Its stability and bioavailability make it a valuable research tool in understanding CoA-related pathways and developing novel therapeutic strategies targeting microbial or metabolic functions.

Reference

1: Yin H, Feng Y, Billon L. Directed Self-Assembly in “Breath Figure” Templating of Melamine-Based Amphiphilic Copolymers: Effect of Hydrophilic End-Chain on Honeycomb Film Formation and Wetting. Chemistry. 2018 Jan 9;24(2):425-433. doi: 10.1002/chem.201704369. Epub 2017 Dec 4. PubMed PMID: 29105167.