Pantothenate kinase-IN-2

• CAT Number: I034199
• CAS Number: 902614-04-4
• Molecular Formula: C21H21N5OS
• Molecular Weight: 391.49
• Purity: ≥95%
• Synonyms: 3-(4,6-dimethyl-3,7,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1,3,5,8,10,12-hexaen-5-yl)-N-(3-methylsulfanylphenyl)propanamide
• InChI: InChI=1S/C21H21N5OS/c1-13-17(9-10-19(27)24-15-6-4-7-16(12-15)28-3)14(2)26-21(23-13)18-8-5-11-22-20(18)25-26/h4-8,11-12H,9-10H2,1-3H3,(H,24,27)
• InChIKey: UNCZUEUPSJKHGB-UHFFFAOYSA-N
• SMILES: CC1=C(C(=NC2=C3C=CC=NC3=NN12)C)CCC(=O)NC4=CC(=CC=C4)SC

Pantothenate kinase-IN-2(CAT: I034199) is a selective small-molecule inhibitor of pantothenate kinase (PanK), the rate-limiting enzyme in coenzyme A (CoA) biosynthesis. By blocking PanK activity, this compound reduces intracellular CoA levels, making it a valuable tool for studying metabolic regulation, energy homeostasis, and lipid metabolism. Pantothenate kinase-IN-2 is particularly useful in research focused on neurodegenerative diseases, such as pantothenate kinase-associated neurodegeneration (PKAN), and other disorders linked to CoA dysregulation. With high potency and specificity, this inhibitor supports target validation, pathway analysis, and the development of novel therapeutics in metabolic and neurological disease research.