PAPA NONOate

• CAT Number: M104907
• CAS Number: 146672-58-4
• Molecular Formula: C6H16N4O2
• Molecular Weight: 176.22
• Purity: ≥95%
• Synonyms: (Z)-[3-aminopropyl(propyl)amino]-hydroxyimino-oxidoazanium
• InChI: InChI=1S/C6H16N4O2/c1-2-5-9(6-3-4-7)10(12)8-11/h11H,2-7H2,1H3/b10-8-
• InChIKey: QODRTFHTYGHQMT-NTMALXAHSA-N
• SMILES: CCCN(CCCN)[N+](=NO)[O-]

PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].
PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3[1].
PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2].

Reference

[1]. Rössig L, et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem. 1999 Mar 12;274(11):6823-6.
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[2]. N Dashti, et al. Study of the effect of PAPA NONOate on the rate of diabetic wound healing. African Journal of Biotechnology. 2014.

[3]. Keefer LK, et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol. 1996;268:281-93.
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