PAR-4 Agonist Peptide, amide TFA

For research use only. Not for therapeutic Use.

  • CAT Number: I019431
  • CAS Number: 1228078-65-6
  • Molecular Formula: C₃₆H₄₉F₃N₈O₉
  • Molecular Weight: 794.82
  • Purity: ≥95%
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PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist[1].<br>Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1].


Catalog Number I019431
CAS Number 1228078-65-6
Molecular Formula C₃₆H₄₉F₃N₈O₉
Purity ≥95%
Reference

[1]. Annaházi A, et al. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Neurogastroenterol Motil. 2012 Jan;24(1):76-85, e13.

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