PAR-4 Agonist Peptide, amide TFA

• CAT Number: I019431
• CAS Number: 1228078-65-6
• Molecular Formula: C₃₆H₄₉F₃N₈O₉
• Molecular Weight: 794.82
• Purity: ≥95%
• IUPAC Name: (2S)-N-[2-[[(2S)-6-amino-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]-1-[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
• InChI: 1S/C34H48N8O7.C2HF3O2/c1-21(36)31(46)41-27(19-23-12-14-24(43)15-13-23)34(49)42-17-7-11-28(42)33(48)38-20-29(44)39-25(10-5-6-16-35)32(47)40-26(30(37)45)18-22-8-3-2-4-9-22;3-2(4,5)1(6)7/h2-4,8-9,12-15,21,25-28,43H,5-7,10-11,16-20,35-36H2,1H3,(H2,37,45)(H,38,48)(H,39,44)(H,40,47)(H,41,46);(H,6,7)/t21-,25-,26-,27-,28-;/m0./s1
• InChIKey: BGPJLFVICWHITH-HKJXYENISA-N
• SMILES: C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N)N.C(=O)(C(F)(F)F)O

PAR-4 Agonist Peptide, amide TFA (Cat No.: I019431) is a synthetic peptide that selectively activates protease-activated receptor 4 (PAR-4), a G protein-coupled receptor involved in platelet activation, inflammation, and vascular biology. The peptide mimics the tethered ligand sequence revealed upon thrombin cleavage of PAR-4, initiating intracellular signaling cascades. The amide form enhances stability, while the trifluoroacetate (TFA) salt improves solubility and handling. It is widely used in cardiovascular and thrombosis research to study PAR-4-mediated pathways and develop targeted antiplatelet or anti-inflammatory therapies.

Reference

[1]. Annaházi A, et al. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Neurogastroenterol Motil. 2012 Jan;24(1):76-85, e13.