Parbendazole

• CAT Number: R042261
• CAS Number: 14255-87-9
• Molecular Formula: C13H17N3O2
• Molecular Weight: 247.29
• Purity: ≥95%
• Synonyms: N-(6-Butyl-1H-benzimidazol-2-yl)carbamic Acid Methyl Ester; 5-Butyl-2-(carbomethoxyamino)benzimidazole; Helatac; Helmatac; Methyl (5-butyl-1H-benzimidazol-2-yl)carbamate; Methyl 5(6)-butyl-2-benzimidazolecarbamate; Methyl 5-butylbenzimidazole-2-carba
• Target: Microtubule/Tubulin
• Storage: -20°C
• IUPAC Name: methyl N-(6-butyl-1H-benzimidazol-2-yl)carbamate
• InChI: InChI=1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17)
• InChIKey: YRWLZFXJFBZBEY-UHFFFAOYSA-N
• SMILES: CCCCC1=CC2=C(C=C1)N=C(N2)NC(=O)OC

Parbendazole（Cat No.:R042261）is a benzimidazole derivative used as an anthelmintic agent to treat parasitic worm infections in animals. It works by binding to β-tubulin, disrupting microtubule formation and impairing essential cellular processes like nutrient uptake and cell division in parasites, leading to their death. Parbendazole is effective against a wide range of gastrointestinal nematodes and is commonly used in veterinary medicine. Recent research has explored its potential anticancer properties, as its mechanism of action can inhibit cancer cell proliferation, making it of interest in oncology research.

Reference

1: Theodorides VJ, Laderman M. Activity of parbendazole upon Trichinella spiralis
in mice. J Parasitol. 1969 Jun;55(3):678. PubMed PMID: 5790389.

2: Chang J, Wescott RB. Anthelmintic activity of parbendazole in swine. Am J Vet
Res. 1969 Jan;30(1):77-9. PubMed PMID: 5812439.

3: Batte EG, Moncol DJ. Evaluation of parbendazole, a new broad spectrum
anthelmintic for swine and sheep. Vet Med Small Anim Clin. 1968 Oct;63(10):984-5.
PubMed PMID: 5188328.

4: Theodorides VJ, Laderman M, Pagano JF. Parbendazole in treatment of intestinal
nematodes of swine. Vet Med Small Anim Clin. 1968 Apr;63(4):370-1. PubMed PMID:
5184664.