Parecoxib Sodium

• CAT Number: I002518
• CAS Number: 198470-85-8
• Molecular Formula: C₁₉H₁₇N₂NaO₄S
• Molecular Weight: 392.42
• Purity: ≥95%
• Synonyms: sodium;[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl-propanoylazanide
• Target: COX
• Solubility: DMSO：≥ 32 mg/mL
• Storage: 2-8°C
• InChI: InChI=1S/C19H18N2O4S.Na/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;/h4-12H,3H2,1-2H3,(H,21,22);/q;+1/p-1
• InChIKey: HQPVVKXJNZEAFW-UHFFFAOYSA-M
• SMILES: CCC(=O)[N-]S(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C.[Na+]

Parecoxib Sodium (Cat No.:I002518) is a selective and orally active COX-2 inhibitor and a prodrug of Valdecoxib. Parecoxib Sodium is a non-steroidal anti-inflammatory agent (NSAID) that inhibits prostaglandin (PG) synthesis. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Schreder H, et al. Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue. Neurochem Int. 2011 Jan;58(1):9-13.
[2]. Ye Z, et al. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β. Neurochem Res. 2012 Feb;37(2):321-9.
[3]. Guo YJ, et al. Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling. Exp Ther Med. 2013 Jul;6(1):275-279.