Paromomycin Sulfate

• CAT Number: A000702
• CAS Number: 1263-89-4
• Molecular Formula: C₂₃H₄₅N₅O₁₄·H₂SO₄
• Molecular Weight: 713.71
• Purity: ≥95%
• Target: Antibiotic
• Storage: 3 years -20C powder
• IUPAC Name: (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
• InChI: InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
• InChIKey: LJRDOKAZOAKLDU-UDXJMMFXSA-N
• SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

Paromomycin sulfate（Cat No.:A000702）is a broad-spectrum aminoglycoside antibiotic derived from Streptomyces rimosus. It inhibits bacterial protein synthesis by binding to the 16S ribosomal RNA of the 30S ribosomal subunit, leading to misreading of mRNA and bacterial death. Paromomycin is effective against a variety of Gram-positive and Gram-negative bacteria, as well as protozoa, including Entamoeba histolytica and Leishmania species. It is used to treat intestinal infections, such as amebiasis and cryptosporidiosis, and as a topical agent for leishmaniasis. Its low systemic absorption ensures targeted efficacy in intestinal infections.

Reference

Davidson, R. N., and et al. /Paromomycin./ Transactions of the Royal Society of Tropical Medicine and Hygiene 103.7 (2009): 653-60. www.ncbi.gov. Web. 6 Sept. 2012.Puglisi, Joseph D., and et al. /Paromomycin Binding Induces a Local Conformational Change in the A-site of 16 S RRNA./ Journal of Molecular Biology 277.2 (1998): 335-45 www.ncbi.gov. Web. 6 Sept. 2012.