For research use only. Not for therapeutic Use.
Paromomycin sulfate is a freely soluble (50 mg/mL) aminoglycoside antibacterial and antiparasitic drug.</br>Like many aminoglycosides, paromomycin targets the 16S rRNA of the 30S ribosomal subunit and prevents translocation and misreading of mRNA by stabilizing aminoacyl-tRNA in the acceptor (“A”) site.
| Catalog Number | A000702 |
| CAS Number | 1263-89-4 |
| Synonyms | NA |
| Molecular Formula | C₂₃H₄₅N₅O₁₄·H₂SO₄ |
| Purity | ≥95% |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18- |
| InChIKey | LJRDOKAZOAKLDU-UDXJMMFXSA-N |
| SMILES | C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O |
| Reference | <p>Davidson, R. N., and et al. /Paromomycin./ <em>Transactions of the Royal Society of Tropical Medicine and Hygiene</em> 103.7 (2009): 653-60. <em>www.ncbi.gov</em>. Web. 6 Sept. 2012.</p><p>Puglisi, Joseph D., and et al. /Paromomycin Binding Induces a Local Conformational Change in the A-site of 16 S RRNA./ <em>Journal of Molecular Biology</em> 277.2 (1998): 335-45 <em>www.ncbi.gov</em>. Web. 6 Sept. 2012.</p></span></p> |
