Paroxetine Hydrochloride

• CAT Number: A000195
• CAS Number: 78246-49-8
• Molecular Formula: C19H21ClFNO3
• Molecular Weight: 365.3
• Purity: ≥95%
• Synonyms: 78246-49-8; Paroxetine Hcl; Paroxat; Aropax 20; (3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride
• Target: Autophagy
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1
• InChIKey: GELRVIPPMNMYGS-RVXRQPKJSA-N
• SMILES: C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl

Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression. It is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors.

Reference

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