For research use only. Not for therapeutic Use.
Selective serotonin reuptake inhibitor (SSRI); Paroxetine is used to treat major depression, obsessive-compulsive, panic, social anxiety, and generalised anxiety disorders in adult outpatients.Paroxetine has also been identified an inhibitor of GRK2 activity both in vitro and in living cells with up to 60-fold selectivity over other GRKs, and is capable of increasing myocardial contractility.
| Catalog Number | I000429 |
| CAS Number | 110429-35-1 |
| Molecular Formula | C19H20FNO3.HCl |
| Purity | ≥95% |
| IUPAC Name | (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrate;dihydrochloride |
| InChI | InChI=1S/2C19H20FNO3.2ClH.H2O/c2*20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;;/h2*1-6,9,14,17,21H,7-8,10-12H2;2*1H;1H2/t2*14-,17-;;;/m00.../s1 |
| SMILES | C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.O.Cl.Cl |
| Reference | S.R. Grimsley et al. Paroxetine, sertraline, and fluvoxamine: new selective serotonin reuptake inhibitors. Clin Pharm. 1992 Nov;11(11):930-57.
D.M. Thal et al. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem Biol. 2012 Nov 16;7(11):1830-9.
L. Weber et al. Paroxetine: a first for selective serotonin reuptake inhibitors – a new use: approved for vasomotor symptoms in postmenopausal women. Womens Health (Lond Engl). 2014 Mar;10(2):147-54. |
