PARP-1-IN-4

• CAT Number: I041145
• CAS Number: 684234-56-8
• Molecular Formula: C22H15Cl2N3O2
• Molecular Weight: 424.28
• Purity: ≥95%
• Synonyms: N-(4-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide
• InChI: InChI=1S/C22H15Cl2N3O2/c23-15-7-5-14(6-8-15)21-18-3-1-2-4-19(18)22(29)27(26-21)13-20(28)25-17-11-9-16(24)10-12-17/h1-12H,13H2,(H,25,28)
• InChIKey: ZYDMHJZNLFTYOR-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=NN(C2=O)CC(=O)NC3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl

PARP-1-IN-4 (Cat No.: I041145) is a potent and selective inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme crucial for DNA damage detection and repair. By blocking PARP-1 activity, this compound enhances DNA damage accumulation, leading to synthetic lethality in cancer cells with homologous recombination deficiencies, such as those with BRCA mutations. PARP-1-IN-4 is widely used in oncology research to investigate DNA repair mechanisms, tumor vulnerability, and combination therapy strategies. For research use only in preclinical and laboratory-based cancer studies.

Reference

[1]. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018;77:443-456.
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