PARP10/15-IN-1

• CAT Number: I043626
• CAS Number: 2892065-01-7
• Molecular Formula: C13H10N2O3S
• Molecular Weight: 274.30
• Purity: ≥95%
• Synonyms: 6-(thiophen-2-ylmethoxy)-2,3-dihydrophthalazine-1,4-dione
• IUPAC Name: 6-(thiophen-3-ylmethoxy)-2,3-dihydrophthalazine-1,4-dione
• InChI: InChI=1S/C13H10N2O3S/c16-12-10-2-1-9(5-11(10)13(17)15-14-12)18-6-8-3-4-19-7-8/h1-5,7H,6H2,(H,14,16)(H,15,17)
• InChIKey: RFKWWUGSOVDNFF-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=C1OCC3=CSC=C3)C(=O)NNC2=O

PARP10/15-IN-1（Cat No.:I043626）is a selective inhibitor of poly(ADP-ribose) polymerases 10 (PARP10) and 15 (PARP15), enzymes involved in the regulation of DNA repair, cellular stress responses, and protein modifications. By inhibiting these enzymes, PARP10/15-IN-1 interferes with the repair of DNA damage and modulates various cellular pathways related to inflammation, cell survival, and proliferation. This compound shows promise as a therapeutic strategy in oncology, particularly for tumors with DNA repair defects. It is also being explored for its potential to enhance the efficacy of chemotherapy and radiation treatments by sensitizing cancer cells.