PARP10/15-IN-1

• CAT Number: I043626
• CAS Number: 2892065-01-7
• Molecular Formula: C13H10N2O3S
• Molecular Weight: 274.30
• Purity: ≥95%
• Synonyms: 6-(thiophen-2-ylmethoxy)-2,3-dihydrophthalazine-1,4-dione
• InChI: InChI=1S/C13H10N2O3S/c16-12-10-4-3-8(6-11(10)13(17)15-14-12)18-7-9-2-1-5-19-9/h1-6H,7H2,(H,14,16)(H,15,17)
• InChIKey: KVMIKZSTQOWDGQ-UHFFFAOYSA-N
• SMILES: C1=CSC(=C1)COC2=CC3=C(C=C2)C(=O)NNC3=O

PARP10/15-IN-1 (compound 8l) is a potent inhibitor of dual inhibitor of PARP10 and PARP15, with IC50s of 160 nM and 370 nM, respectively. PARP10/15-IN-1 can be used for cancer[1].

Reference

[1]. Nizi MG, et, al. Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem. 2022 Apr 19;237:114362.
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