For research use only. Not for therapeutic Use.
PARP10/15-IN-2 (Compound 8h) is a potent PARP10 and PARP15 dual inhibitor with IC50 values of 0.15 µM and 0.37 µM against PARP10 and PARP15, respectively. PARP10/15-IN-2 is able to enter cells and rescue cells from apoptosis[1].
| Catalog Number | I043615 |
| CAS Number | 2892064-99-0 |
| Synonyms | 6-[(2-fluorophenyl)methoxy]-2,3-dihydrophthalazine-1,4-dione |
| Molecular Formula | C15H11FN2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H11FN2O3/c16-13-4-2-1-3-9(13)8-21-10-5-6-11-12(7-10)15(20)18-17-14(11)19/h1-7H,8H2,(H,17,19)(H,18,20) |
| InChIKey | GJJIICZAOJXOEJ-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)COC2=CC3=C(C=C2)C(=O)NNC3=O)F |
| Reference | [1]. Nizi MG, et al. Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem. 2022 Jul 5;237:114362. |
