PARP10/15-IN-2

• CAT Number: I043615
• CAS Number: 2892064-99-0
• Molecular Formula: C15H11FN2O3
• Molecular Weight: 286.26
• Purity: ≥95%
• Synonyms: 6-[(2-fluorophenyl)methoxy]-2,3-dihydrophthalazine-1,4-dione
• InChI: InChI=1S/C15H11FN2O3/c16-13-4-2-1-3-9(13)8-21-10-5-6-11-12(7-10)15(20)18-17-14(11)19/h1-7H,8H2,(H,17,19)(H,18,20)
• InChIKey: GJJIICZAOJXOEJ-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)COC2=CC3=C(C=C2)C(=O)NNC3=O)F

PARP10/15-IN-2（Cat No.:I043615）is a small-molecule inhibitor targeting poly(ADP-ribose) polymerases 10 (PARP10) and 15 (PARP15), enzymes involved in DNA repair, cellular stress responses, and regulation of protein function through ADP-ribosylation. By inhibiting these enzymes, PARP10/15-IN-2 disrupts the repair of DNA damage and modulates key cellular processes, making it a promising candidate for cancer treatment. It enhances the sensitivity of tumor cells to DNA-damaging therapies, such as chemotherapy and radiation. PARP10/15-IN-2 is also being studied for its potential to treat diseases associated with defective DNA repair mechanisms.