PARP10/15-IN-3

• CAT Number: I043614
• CAS Number: 2892064-88-7
• Molecular Formula: C15H18N2O3
• Molecular Weight: 274.32
• Purity: ≥95%
• Synonyms: 6-(cyclopropylmethoxy)-2,3-dihydrophthalazine-1,4-dione
• InChI: InChI=1S/C12H12N2O3/c15-11-9-4-3-8(17-6-7-1-2-7)5-10(9)12(16)14-13-11/h3-5,7H,1-2,6H2,(H,13,15)(H,14,16)
• InChIKey: IURJTWHWLCVJAK-UHFFFAOYSA-N
• SMILES: C1CC1COC2=CC3=C(C=C2)C(=O)NNC3=O

PARP10/15-IN-3 (Compound 8a) is a potent PARP10 and PARP15 dual inhibitor with IC50 values of 0.14 µM and 0.40 µM against PARP10 and PARP15, respectively. PARP10/15-IN-3 is able to enter cells and rescue cells from apoptosis[1].

Reference

[1]. Nizi MG, et al. Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem. 2022 Jul 5;237:114362.
 [Content Brief]