For research use only. Not for therapeutic Use.
PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1].
PARP10-IN-2 (compound 10) has an IC50 of 1-2 μM by olony‐formation assay (CFA) in HeLa‐PARP10 cells[1].
| Catalog Number | I041980 |
| CAS Number | 1042780-52-8 |
| Synonyms | 4-(4-cyanophenoxy)benzamide |
| Molecular Formula | C14H10N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H10N2O2/c15-9-10-1-5-12(6-2-10)18-13-7-3-11(4-8-13)14(16)17/h1-8H,(H2,16,17) |
| InChIKey | PQQFJYPJKKMNMX-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C#N)OC2=CC=C(C=C2)C(=O)N |
| Reference | [1]. Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948. |
