For research use only. Not for therapeutic Use.
PARP10-IN-3 is a selective mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10. PARP10-IN-3 reveals potent inhibition on PARP2 and PARP15 with IC50s of 1.7 μM for human PARP2 and human PARP15, respectively[1].
PARP10-IN-3 (compound 20) has an IC50 of 1-2 μM by olony‐formation assay (CFA) in HeLa‐PARP10 cells[1].
Catalog Number | I041979 |
CAS Number | 2225800-19-9 |
Synonyms | 3-(4-carbamoylphenoxy)benzamide |
Molecular Formula | C14H12N2O3 |
Purity | ≥95% |
InChI | InChI=1S/C14H12N2O3/c15-13(17)9-4-6-11(7-5-9)19-12-3-1-2-10(8-12)14(16)18/h1-8H,(H2,15,17)(H2,16,18) |
InChIKey | PMOXYDXLQIUWHL-UHFFFAOYSA-N |
SMILES | C1=CC(=CC(=C1)OC2=CC=C(C=C2)C(=O)N)C(=O)N |
Reference | [1]. Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948. |