PARP10-IN-3

For research use only. Not for therapeutic Use.

  • CAT Number: I041979
  • CAS Number: 2225800-19-9
  • Molecular Formula: C14H12N2O3
  • Molecular Weight: 256.26
  • Purity: ≥95%
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PARP10-IN-3 is a selective mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10. PARP10-IN-3 reveals potent inhibition on PARP2 and PARP15 with IC50s of 1.7 μM for human PARP2 and human PARP15, respectively[1].
PARP10-IN-3 (compound 20) has an IC50 of 1-2 μM by olony‐formation assay (CFA) in HeLa‐PARP10 cells[1].


Catalog Number I041979
CAS Number 2225800-19-9
Synonyms

3-(4-carbamoylphenoxy)benzamide

Molecular Formula C14H12N2O3
Purity ≥95%
InChI InChI=1S/C14H12N2O3/c15-13(17)9-4-6-11(7-5-9)19-12-3-1-2-10(8-12)14(16)18/h1-8H,(H2,15,17)(H2,16,18)
InChIKey PMOXYDXLQIUWHL-UHFFFAOYSA-N
SMILES C1=CC(=CC(=C1)OC2=CC=C(C=C2)C(=O)N)C(=O)N
Reference

[1]. Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948.
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