PARP11 inhibitor ITK7

• CAT Number: I042024
• CAS Number: 2411890-36-1
• Molecular Formula: C17H14N4OS
• Molecular Weight: 322.38
• Purity: ≥95%
• Synonyms: 8-methyl-7-prop-1-ynyl-2-(pyrimidin-2-ylsulfanylmethyl)-3H-quinazolin-4-one
• InChI: InChI=1S/C17H14N4OS/c1-3-5-12-6-7-13-15(11(12)2)20-14(21-16(13)22)10-23-17-18-8-4-9-19-17/h4,6-9H,10H2,1-2H3,(H,20,21,22)
• InChIKey: VRECINGNBPANGK-UHFFFAOYSA-N
• SMILES: CC#CC1=C(C2=C(C=C1)C(=O)NC(=N2)CSC3=NC=CC=N3)C

PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor. PARP11 inhibitor ITK7 can potently inhibit PARP11 with an IC50 value of 14 nM. PARP11 inhibitor ITK7 can be used for the research of cellular localization[1].
PARP11 inhibitor ITK7 (ITK7) can potently inhibit PARP11 with an IC50 value of 14 nM[1].
ITK7 exhibits a dose-dependent inhibition of PARP11-dependent auto-MARylation with an EC50 value of 13 nM[1].
ITK7 (0, 0.03, 0.1, 0.3, 1, 3 μM; 3 h) inhibits PARP11 auto-MARylation activity in cells and causes PARP11 to dissociate from the nuclear
envelope[1].

Reference

[1]. Kirby, Ilsa T et al. A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity. Cell chemical biology vol. 25,12 (2018): 1547-1553.e12.
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