For research use only. Not for therapeutic Use.
Parthenolide(CAT: I002583) is a naturally occurring sesquiterpene lactone and a potent NF-κB pathway inhibitor, widely studied for its anti-inflammatory and anticancer properties. By inhibiting IκB kinase (IKK) activity, it prevents NF-κB activation, thereby reducing the expression of pro-inflammatory cytokines and survival signals in cancer cells. Additionally, it induces oxidative stress and apoptosis in malignant cells, making it a valuable tool in oncology and immunology research. Parthenolide is extensively used to explore therapeutic approaches for inflammatory disorders, leukemia, and solid tumors, providing a foundation for developing targeted treatments and combination therapies.
| Catalog Number | I002583 |
| CAS Number | 20554-84-1 |
| Synonyms | (1aR,7aS,10aS,10bS,E)-1a,5-dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[2/’,3/’:9,10]cyclodeca[1,2-b]furan-9(1aH)-one |
| Molecular Formula | C₁₅H₂₀O₃ |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20C powder |
| IUPAC Name | (1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one |
| InChI | InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1 |
| InChIKey | KTEXNACQROZXEV-PVLRGYAZSA-N |
| SMILES | CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C |
| Reference | </br>1:Parthenolide promotes apoptotic cell death and inhibits the migration and invasion of SW620 cells. Liu YC, Kim SL, Park YR, Lee ST, Kim SW.Intest Res. 2017 Apr;15(2):174-181. doi: 10.5217/ir.2017.15.2.174. Epub 2017 Apr 27. PMID: 28522946 </br>2:Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth via B-Raf/MAPK/Erk pathway. Lin M, Bi H, Yan Y, Huang W, Zhang G, Zhang G, Tang S, Liu Y, Zhang L, Ma J, Zhang J.Oncotarget. 2017 Apr 4;8(14):23436-23447. doi: 10.18632/oncotarget.15584. PMID: 28423582 Free PMC Article</br>3:Parthenolide Selectively Sensitizes Prostate Tumor Tissue to Radiotherapy while Protecting Healthy Tissues In Vivo. Morel KL, Ormsby RJ, Bezak E, Sweeney CJ, Sykes PJ.Radiat Res. 2017 May;187(5):501-512. doi: 10.1667/RR14710.1. Epub 2017 Mar 3. PMID: 28398879 </br>4:Parthenolide reduces gene transcription of prosurvival mediators in U937 cells. Mohammadi S, Zahedpanah M, Nikbakht M, Shaiegan M, Hamidollah G, Nikugoftar M, Rahmani B, Hamedi Asl D.Exp Oncol. 2017 Mar;39(1):30-35. PMID: 28361855 </br>5:Parthenolide attenuates cerebral ischemia/reperfusion injury via Akt/GSK-3β pathway in PC12 cells. Zhang JF, Zhang L, Shi LL, Zhao ZH, Xu H, Liang F, Li HB, Zhao Y, Xu X, Yang K, Tian YF.Biomed Pharmacother. 2017 May;89:1159-1165. doi: 10.1016/j.biopha.2017.03.009. Epub 2017 Mar 24. PMID: 28314243 </br>6:Parthenolide inhibits the initiation of experimental autoimmune neuritis. Zhang M, Liu RT, Zhang P, Zhang N, Yang CL, Yue LT, Li XL, Liu Y, Li H, Du J, Duan RS.J Neuroimmunol. 2017 Apr 15;305:154-161. doi: 10.1016/j.jneuroim.2017.02.003. Epub 2017 Feb 8. PMID: 28284336 </br>7:Synthesis of dual-action parthenolide prodrugs as potent anticancer agents. Taleghani A, Nasseri MA, Iranshahi M.Bioorg Chem. 2017 Apr;71:128-134. doi: 10.1016/j.bioorg.2017.01.020. Epub 2017 Feb 1. PMID: 28215600 </br>8:Parthenolide suppresses pancreatic cell growth by autophagy-mediated apoptosis. Liu W, Wang X, Sun J, Yang Y, Li W, Song J.Onco Targets Ther. 2017 Jan 23;10:453-461. doi: 10.2147/OTT.S117250. eCollection 2017. PMID: 28176967 Free PMC Article</br>9:Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-κB Activation. Kim SL, Kim SH, Park YR, Liu YC, Kim EM, Jeong HJ, Kim YN, Seo SY, Kim IH, Lee SO, Lee ST, Kim SW.Mol Cancer Res. 2017 Feb;15(2):141-151. doi: 10.1158/1541-7786.MCR-16-0101. Epub 2016 Nov 14. PMID: 28108625 </br>10:Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives. Yang Z, Kuang B, Kang N, Ding Y, Ge W, Lian L, Gao Y, Wei Y, Chen Y, Zhang Q.Eur J Med Chem. 2017 Feb 15;127:296-304. doi: 10.1016/j.ejmech.2016.12.044. Epub 2016 Dec 23. PMID: 28068601 |
