For research use only. Not for therapeutic Use.
PAT-1251 (CAT: I008562) is a potent, selective, and orally efficacious inhibitor of the copper-dependent amine oxidase, lysyl oxidase-like 2 (LOXL2). LOXL2 is an enzyme involved in the crosslinking of extracellular matrix components, and its overexpression has been implicated in various fibrotic diseases and cancer progression. By inhibiting LOXL2, PAT-1251 has the potential to disrupt fibrosis and tumor growth. Further research and development are ongoing to explore the therapeutic applications of PAT-1251 in the treatment of fibrotic diseases and cancer.
| Catalog Number | I008562 |
| CAS Number | 2007885-39-2 |
| Synonyms | PAT-1251; PAT 1251; PAT1251.;(3-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone |
| Molecular Formula | C18H17F4N3O3 |
| Purity | ≥95% |
| Target | Monoamine Oxidase |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IC50 | 0.074 μM |
| InChI | InChI=1S/C18H17F4N3O3/c19-13-8-25(9-14(13)26)17(27)11-2-1-3-12(6-11)28-16-5-10(7-23)4-15(24-16)18(20,21)22/h1-6,13-14,26H,7-9,23H2/t13-,14-/m1/s1 |
| InChIKey | ODGXXYXJORZPHE-ZIAGYGMSSA-N |
| SMILES | O=C(C1=CC=CC(OC2=NC(C(F)(F)F)=CC(CN)=C2)=C1)N3C[C@@H](F)[C@H](O)C3 |
| Reference | </br>1:Rowbottom MW, Bain G, Calderon I, Lasof T, Lonergan D, Lai A, Huang F, Darlington J, Prodanovich P, Santini AM, King CD, Goulet L, Shannon KE, Ma GL, Nguyen K, MacKenna DA, Evans JF, Hutchinson JH. Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem. 2017 May 15. doi: 10.1021/acs.jmedchem.7b00345. [Epub ahead of print] PubMed PMID: 28471663. |
