Pazufloxacin mesylate

• CAT Number: I002126
• CAS Number: 163680-77-1
• Molecular Formula: C17H19FN2O7S
• Molecular Weight: 414.41
• Purity: ≥95%
• Target: Bacterial
• Solubility: DMSO:45mg/mL
• Storage: Store at -20°C
• IUPAC Name: (2S)-6-(1-aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;methanesulfonic acid
• InChI: InChI=1S/C16H15FN2O4.CH4O3S/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22;1-5(2,3)4/h4-5,7H,2-3,6,18H2,1H3,(H,21,22);1H3,(H,2,3,4)/t7-;/m0./s1
• InChIKey: UDHGFPATQWQARM-FJXQXJEOSA-N
• SMILES: C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2C4(CC4)N)F)C(=O)O.CS(=O)(=O)O

Pazufloxacin mesylate（Cat No.:I002126）is a broad-spectrum fluoroquinolone antibiotic with potent activity against a wide range of Gram-negative and Gram-positive bacteria. It acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and cell division. Pazufloxacin mesylate is used for the treatment of various bacterial infections, including respiratory and urinary tract infections. It offers enhanced efficacy against certain resistant strains compared to older fluoroquinolones. With a favorable pharmacokinetic profile, it is suitable for both intravenous and oral administration in clinical settings.

Reference

[1]. Fukuoka, Y., et al., In vitro and in vivo antibacterial activities of T-3761, a new quinolone derivative. Antimicrob Agents Chemother, 1993. 37(3): p. 384-92.

[2]. Muratani, T., M. Inoue, and S. Mitsuhashi, In vitro activity of T-3761, a new fluoroquinolone. Antimicrob Agents Chemother, 1992. 36(10): p. 2293-303.