For research use only. Not for therapeutic Use.
PB131 is a selective and brain-permeable HDAC6 inhibitor with high binding affinity (IC50: 1.8 nM). PB131 has potent anti-inflammatory activity. PB131 can be used for research of inflammation, especially neuroinflammation[1].
| Catalog Number | I041002 |
| CAS Number | 2924425-63-6 |
| Synonyms | 4-(3,4-dihydro-2H-1,8-naphthyridin-1-ylmethyl)-3-fluoro-N-hydroxybenzamide |
| Molecular Formula | C16H16FN3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H16FN3O2/c17-14-9-12(16(21)19-22)5-6-13(14)10-20-8-2-4-11-3-1-7-18-15(11)20/h1,3,5-7,9,22H,2,4,8,10H2,(H,19,21) |
| InChIKey | IRALAZOBAVZSHO-UHFFFAOYSA-N |
| SMILES | C1CC2=C(N=CC=C2)N(C1)CC3=C(C=C(C=C3)C(=O)NO)F |
| Reference | [1]. Liu G, et al. Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors. Eur J Med Chem. 2023 Jun 5;254:115327. |
