PBENZ-DBRMD

• CAT Number: I047678
• CAS Number: 1454662-41-9
• Molecular Formula: C11H5Br2NO4
• Molecular Weight: 374.97
• Purity: ≥95%
• IUPAC Name: 4-(3,4-dibromo-2,5-dioxopyrrol-1-yl)benzoic acid
• InChI: InChI=1S/C11H5Br2NO4/c12-7-8(13)10(16)14(9(7)15)6-3-1-5(2-4-6)11(17)18/h1-4H,(H,17,18)
• SMILES: C1=CC(=CC=C1C(=O)O)N2C(=O)C(=C(C2=O)Br)Br

First-in-class iodothyronine deiodinase type 3 (DIO3) inhibitor, demonstrating attenuated cell counts, induction in apoptosis, and a reduction in cell proliferation in DIO3-positive HGSOC cells (OVCAR3 and KURAMOCHI).
KEYWORDS: PBENZ-DBRMD | Supplier | DIO3 Inhibitor | CAS [1454662-41-9] | DIO3 | Deiodinase type 3 | Inhibitor | Enzymes

Reference

D Moskovich et al. Targeting the DIO3 enzyme using first-in-class inhibitors effectively suppresses tumor growth: a new paradigm in ovarian cancer treatment. Oncogene. 2021;40(44):6248-6257.