For research use only. Not for therapeutic Use.
PBOX 6（Cat No.:I012910） is a compound belonging to the pyrrolo-1,5-benzoxazepine (PBOX) family. It functions as a microtubule depolymerizer, disrupting the structure and dynamics of microtubules. By interfering with microtubule function, PBOX 6 exerts pro-apoptotic effects, promoting programmed cell death. These properties make PBOX 6 a potential candidate for anti-cancer therapies, as it targets the cytoskeleton and induces apoptosis, which could inhibit the growth and proliferation of cancer cells.
| Catalog Number | I012910 |
| CAS Number | 290814-68-5 |
| Molecular Formula | C₂₅H₂₀N₂O₃ |
| Purity | ≥95% |
| Target | Cytoskeleton |
| Solubility | DMSO |
| Storage | 2-8°C |
| IUPAC Name | (6-naphthalen-1-ylpyrrolo[2,1-d][1,5]benzoxazepin-7-yl) N,N-dimethylcarbamate |
| InChI | InChI=1S/C25H20N2O3/c1-26(2)25(28)30-24-21-14-8-16-27(21)20-13-5-6-15-22(20)29-23(24)19-12-7-10-17-9-3-4-11-18(17)19/h3-16H,1-2H3 |
| InChIKey | SOIZAFVNIXAZFQ-UHFFFAOYSA-N |
| SMILES | CN(C)C(=O)OC1=C(OC2=CC=CC=C2N3C1=CC=C3)C4=CC=CC5=CC=CC=C54 |
| Reference | [1]. Zisterer DM, et al. Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents. J Pharmacol Exp Ther. 2000 Apr;293(1):48-59.<br>[2]. Mc Gee MM, et al. Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6. FEBS Lett. 2002 Mar 27;515(1-3):66-70.<br>[3]. Bane FT, et al. The microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1, in malignant hematopoietic cells. J Pharmacol Exp Ther. 2009 Apr;329(1):38-47. |
